Saeki, K., Wood, I. S.*, Wang, W. C. K.*, Patil, S., Sun, Y., Schaeffer, D. F., Su, G. H., & Kopp, J. L. (2024). Acvr1b Loss Increases Formation of Pancreatic Precancerous Lesions From Acinar and Ductal Cells of Origin. Cellular and Molecular Gastroenterology and Hepatology, 18(5), 101387. https://doi.org/10.1016/j.jcmgh.2024.101387

​Wang, S.*, Dong, X., Maazi, M., Chen, N., Mahil, A., & Kopp, J. L. (2023). GABA treatment does not induce neogenesis of new endocrine cells from pancreatic ductal cells. Islets, 15(1). https://doi.org/10.1080/19382014.2023.2219477
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​Zhang, A. M. Y.*, Xia, Y. H., Lin, J. S. H., Chu, K. H.*, Wang, W. C. K.*, Ruiter, T. J. J., Yang, J. C. C., Chen, N., Chhuor, J., Patil, S., Cen, H. H., Rideout, E. J., Richard, V. R., Schaeffer, D. F., Zahedi, R. P., Borchers, C. H., Johnson, J. D., & Kopp, J. L. (2023). Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation. Cell Metabolism, 35(12), 2119-2135.e5. https://doi.org/10.1016/j.cmet.2023.10.003

Tixi, W., Maldonado, M., Chang, Y.-T., Chiu, A., Yeung, W., Parveen, N., Nelson, M. S., Hart, R., Wang, S., Hsu, W. J., Fueger, P., Kopp, J. L., Huising, M. O., Dhawan, S., & Shih, H. P. (2023). Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation. ELife, 12. https://doi.org/10.7554/eLife.90006

Magenheim, J., Maestro, M. A., Sharon, N., Herrera, P. L., Murtaugh, L. C., Kopp, J., Sander, M., Gu, G., Melton, D. A., Ferrer, J., & Dor, Y. (2023). Matters arising: Insufficient evidence that pancreatic β cells are derived from adult ductal Neurog3-expressing progenitors. Cell Stem Cell, 30(4), 488-497.e3. https://doi.org/10.1016/j.stem.2023.03.003

Taylor, A. J., Panzhinskiy, E., Orban, P. C., Lynn, F. C., Schaeffer, D. F., Johnson, J. D., Kopp, J. L., & Verchere, C. B. (2023). Islet amyloid polypeptide does not suppress pancreatic cancer. Molecular Metabolism, 68, 101667. https://doi.org/10.1016/j.molmet.2023.101667

Mastracci, T. L., Apte, M., Amundadottir, L. T., Alvarsson, A., Artandi, S., Bellin, M. D., Bernal-Mizrachi, E., Caicedo, A., Campbell-Thompson, M., Cruz-Monserrate, Z., el Ouaamari, A., Gaulton, K. J., Geisz, A., Goodarzi, M. O., Hara, M., Hull-Meichle, R. L., Kleger, A., Klein, A. P., Kopp, J. L., … Sander, M. (2023). Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes, 72(4), 433–448. https://doi.org/10.2337/db22-0942

​Zhang, A.M.Y*, Chu, K. H., Daly, B. F.*, Ruiter, T., Dou, Y., Yang, J. C. C., de Winter, T. J. J., Chhuor, J., Wang, S., Flibotte, S., Zhao, Y. B., Hu, X., Li, H., Rideout, E. J., Schaeffer, D. F., Johnson, J. D., & Kopp, J. L. (2022). Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics. Cancer & Metabolism, 10(1), 5. https://doi.org/10.1186/s40170-022-00282-z

Patil, S., Dou, Y., & Kopp, J. L. (2022). Cell Type of Pancreatic Ductal Adenocarcinoma Origin: Implications for Prognosis and Clinical Outcomes. Visceral Medicine, 38(1), 4–10. https://doi.org/10.1159/000520946

Mastracci, T. L., Apte, M., Amundadottir, L. T., Alvarsson, A., Artandi, S., Bellin, M. D., Bernal-Mizrachi, E., Caicedo, A., Campbell-Thompson, M., Cruz-Monserrate, Z., el Ouaamari, A., Gaulton, K. J., Geisz, A., Goodarzi, M. O., Hara, M., Hull-Meichle, R. L., Kleger, A., Klein, A. P., Kopp, J. L., … Pandol, S. J. (2022). Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases. Pancreas, 51(9), 1061–1073. https://doi.org/10.1097/MPA.0000000000002170

Erener, S., Ellis, C. E., Ramzy, A., Glavas, M. M., O’Dwyer, S., Pereira, S., Wang, T., Pang, J., Bruin, J. E., Riedel, M. J., Baker, R. K., Webber, T. D., Lesina, M., Blüher, M., Algül, H., Kopp, J. L., Herzig, S., & Kieffer, T. J. (2021). Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer progression in mice. Cell Reports Medicine, 2(11), 100434. https://doi.org/10.1016/j.xcrm.2021.100434
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Zhang AMY*, Wellberg EA, Kopp JL, Johnson JD. Hyperinsulinemia in Obesity, Inflammation, and Cancer. Diabetes Metab J. 2021 Jul;45(4):622. doi: 10.4093/dmj.2021.0131

Espinet E, Gu Z, Imbusch CD, Giese NA, Büscher M, Safavi M, Weisenburger S, Klein C, Vogel V, Falcone M, Insua-Rodríguez J, Reitberger M, Thiel V, Kossi SO, Muckenhuber A, Sarai K, Lee AYL, Backx E, Zarei S, Gaida MM, Rodríguez-Paredes M, Donato E, Yen HY, Eils R, Schlesner M, Pfarr N, Hackert T, Plass C, Brors B, Steiger K, Weichenhan D, Arda HE, Rooman I, Kopp JL, Strobel O, Weichert W, Sprick MR, Trumpp A. Aggressive PDACs Show Hypomethylation of Repetitive Elements and the Execution of an Intrinsic IFN Program Linked to a Ductal Cell of Origin. Cancer Discov. 2021 Mar;11(3):638-659. doi: 10.1158/2159-8290.CD-20-1202.

Ye J, Huang A, Wang H, Zhang AMY*, Huang X, Lan Q, Sato T, Goyama S, Kurokawa M, Deng C, Sander M, Schaeffer DF, Li W, Kopp JL, Xie R. PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response. Cell Death Dis. 2020 Mar 16;11(3):187. doi: 10.1038/s41419-020-2371-x.

Zhang AMY*, Magrill J, de Winter TJJ, Hu X, Skovsø S, Schaeffer DF, Kopp JL, Johnson JD. Endogenous Hyperinsulinemia Contributes to Pancreatic Cancer Development. Cell Metab. 2019 Sep 3;30(3):403-404. doi: 10.1016/j.cmet.2019.07.003.
​Shi, C., Pan, F.C., Kim, J.N., Washington, M.K., Padmanabhan, C., Meyer, C.T., Kopp, J.L., Sander, M, Gannon, M., Beauchamp, R.D., Wright, C.V., Means, A.L. Differential cell susceptibilities to KrasG12D in the setting of obstructive chronic pancreatitis. Cell Mol Gastroenterol Hepatol. 2019 Jul 13. pii: S2352-345X(19)30088-8. doi: 10.1016/j.jcmgh.2019.07.001. 

Das, K., Heeg, S., Reichert, M., Bakir, B., Takano, S., Kopp, J.L., Wahl-Feuerstein, A., Hicks, P., Sander, M., and Rustgi, A. ETV5 regulates ductal morphogenesis with Sox9 and is critical for regeneration from pancreatitis. Dev Dyn. 2018 Jun;247(6):854-866. doi: 10.1002/dvdy.24626. 
Lee A.Y.L.*, Dubois C.L., Sarai K.*, Zarei S.*, Schaeffer D.F., Sander M., Kopp J.L. Cell of origin affects tumour development and phenotype in pancreatic ductal adenocarcinoma. Gut. 2018 Jan 23. pii: gutjnl-2017-314426. doi: 10.1136/gutjnl-2017-314426.

Kopp J.L., Dubois C.L., Schaeffer D.F., Samani A.*, Taghizadeh F.*, Cowan R.W., Rhim A.D., Stiles B.L., Valasek M., Sander M. Loss of PTEN and Activation of Kras Synergistically Induce Formation of Intraductal Papillary Mucinous Neoplasia From Pancreatic Ductal Cells in Mice. Gastroenterology. 2018 Apr;154(5):1509-1523.e5. doi: 10.1053/j.gastro.2017.12.007.

Urtatiz O., Samani A.M.V.*, Kopp J.L., Van Raamsdonk C.D. Rapid melanoma induction in mice expressing oncogenic BrafV600Eusing Mitf-cre. Pigment Cell Melanoma Res. 2017 Jul;31(4):541-544. doi: 10.1111/pcmr.12680

Barrionuevo F.J., Hurtado A., Kim G.J., Real F.M., Bakkali M., Kopp J.L., Sander M., Scherer G., Burgos M., Jiménez R. Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration. Elife. 2016 Jun 21;5. pii: e15635.

Fox R.G., Lytle N.K., Jaquish D.V., Park F.D., Ito T., Bajaj J., Koechlein C.S., Zimdahl B., Yano M.,Kopp J.L., Kritzik M., Sicklick J.K., Sander M., Grandgenett P.M., Hollingsworth M.A., Shibata S., Pizzo D., Valasek M.A., Sasik R., Scadeng M., Okano H., Kim Y., MacLeod A.R., Lowy A.M., Reya T. Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma.Nature. 2016 Jun 16;534(7607):407-11.
​Kopp, J.L., Grompe, M., Sander, M. Tissue regeneration in the liver and pancreas: plasticity or stem cells? Nature Cell Biology. 2016; 18(3):238-45.

Font-Burgada J., Shalapour S., Ramaswamy S., Hsueh B., Rossell D., Umemura A., Taniguchi K., Nakagawa H., Valasek M.A., Ye L., Kopp J.L., Sander M., Carter H., Deisseroth K., Verma I.M., Karin M. Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer. Cell. 2015; 162(4):766-779.
De Vas, M.G., Kopp, J.L., Heliot, C., Sander, M., Cereghini, S., and Haumaitre, C. HNF1B controls pancreas morphogenesis and generation of NGN3+ endocrine progenitors. Development. 2015; Mar 1;142(5):871-82.

​Malhotra, G.K., Zhao, X., Edwards, E., Kopp, J.L., Naramura, M., Sander, M., Band, H., Band, V. The role of Sox9 in mouse mammary gland development and maintenance of mammary stem and luminal progenitor cells. BMC Developmental Biology. 2014; 14(1):47.

Kopp, J.L. and Sander, M. New insights into the cell lineage of pancreatic ductal adenocarcinoma: Evidence for tumor stem cells in premalignant lesions? [Editorial] Gastroenterology. 2013; 146(1):24-26.
Rockich, B.E., Hrycaj, S.M., Shih, H.P., Nagy, M.S., Ferguson, M.A., Kopp, J.L., Sander, M., Wellik, D.M., Spence, J.R. Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. Proc Natl Acad Sci USA. 2013; 110(47):E4456-64.

Kopp, J.L., von Figura, G., Mayes, E., Liu, F-F., Dubois, C.L., Morris IV, J.P., Pan, F.C., Akiyama, H., Wright, C.V.E., Jensen, J., Hebrok, M., Sander, M. Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell. 2012; 22(6):737-750.

Shih, H.P., Kopp, J.L., Sandhu, M., Dubois, C.L., Seymour, P.A., Grapin-Bottom, A., Sander, M. A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation. Development. 2012; 139(14):2488-2499.
Carpentier R., Suñer R.E., Van Hul N., Kopp J.L., Beaudry J.B., Cordi S., Antoniou A., Raynaud P., Lepreux S., Jacquemin P., Leclercq I.A., Sander M., Lemaigre F.P. Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes and adult liver progenitor cells. Gastroenterology. 2011; 141(4):1432-1438.

Dorrell, C., Erker, L., Schug, J., Kopp, J.L., Canaday, P.S., Fox, A.J., Smirnova, O., Duncan, A.W., Finegold, M.J., Sander, M., Kaestner, K.H., Grompe, M. Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice. Genes Dev. 2011; 25(11):1193-203.

Kopp, J.L., Dubois, C.L., Hao, E., Thorel, F., Herrera, P.L., Sander, M. Progenitor cell domains in the developing and adult pancreas. Cell Cycle. 2011; 10(12):1921-1927.

Kopp, J.L., Dubois, C.L., Schaffer A.E., Hao, E., Shih, H.P., Seymour, P.A., Ma, J., Sander, M. Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development. 2011; 138(4):653-65.

Kopp, J.L., Ormsbee, B., Desler, M., Rizzino, A. Small increases in the level of Sox2 trigger the differentiation of mouse embryonic stem cells. Stem Cells. 2008; 26:903-911.

Boer, B., Kopp, J., Desler, M., Mallanna, S., Chakravarthy, H., Wilder, P.J., Bernadt, C.T., and Rizzino, A. Elevating the levels of Sox2 in embryonal carcinoma cells inhibits the expression of Sox2:Oct-3/4 target genes. Nucleic Acids Res. 2007; 35(6):1773-86.

Kopp, J.L., Wilder, P.J., Desler, M., Kinarsky, L., Rizzino, A.  Different domains of the transcription factor Elf3 are required in a promoter-specific manner and multiple domains control its binding to DNA. J Biol Chem. 2007; 282(5):3027-41.

Boer, B., Bernadt, C.T., Desler, M., Wilder, P.J., Kopp, J.L., Rizzino, A.  Differential activities of the FGF-4 enhancer in F9 and P19 embryonal carcinoma cells. J Cell Physiol. 2006; 208(1):97-108.

​Kopp, J.L., Wilder, P.J., Desler, M., Kim, J.H., Hou, J. Nowling, T., and Rizzino, A. Unique and selective effects of five Ets family members, Elf3, Ets1, Ets2, PEA3, and PU.1, on the promoter of the Type II Transforming Growth Factor-Beta Receptor gene. J Biol Chem. 2004; 279(19):19407-20.

*Indicates Kopp lab trainees.